Arne Slot’s side remain perfect in the Premier League this term, sneaking a 1-0 win over Burnley at the death at Turf Moor last weekend.
As for Atleti, they have had a bit more of a stuttering start to the season, winning one of their opening four La Liga matches, drawing two and losing the other.
That said, Diego Simeone’s men beat Villarreal last time out, with Pablo Barrios and Nico Gonzalez both on the scoresheet.
Liverpool are gunning for a seventh European crown this year, having been knocked out in the last 16 by eventual winners Paris Saint-Germain last term.
Date, kick-off time and venue
Liverpool vs Atletico Madrid is scheduled for a 8pm BST kick-off on Tuesday September 16, 2025.
The match will take place at Anfield in Liverpool.
Where to watch Liverpool vs Atletico Madrid
TV channel: In the UK, the game will be televised live TNT Sports 1. Coverage begins at 7pm BST.
Live stream: TNT Sports subscribers can also catch the contest live online via the Discovery+ app and website.
Live blog: You can follow all the action on Wednesday evening via Standard Sport’s dedicated live match blog.
Liverpool vs Atletico Madrid team news
The big talking point here is whether Alexander Isak will finally make his bow in a Liverpool shirt after one of the longest transfer sagas in recent history.
Elsewhere, Curtis Jones also missed out last weekend with an unknown injury.
Liverpool’s flurry of summer signings will have a chance to make their Champions League debuts here. The likes of Jeremie Frimpong, who returned to action from injury on Sunday, Florian Wirtz, Hugo Ekitike, Milos Kerkez, and Giovanni Leoni could all make European bows for their new club.
As for Atleti, Simeone has four injury concerns ahead of his trip to Merseyside.
Julian Alvarez, the former Man City striker, was forced off at the weekend with a knee injury, and the same can be said of David Hancko and Robin Le Normand, who both came off with ankle and back problems respectively. Goalscorer Gonzalez was also withdrawn with cramp.
The Spaniards had already been without centre-back Jose Maria Gimenez, midfielder Thiago Almada and winger Alex Baena.
Liverpool vs Atletico Madrid prediction
Off form alone, this should be a routine Liverpool victory, but Atletico are always a tricky customer in the Champions League.
The last two times these teams met, the La Liga outfit had a man sent off, with Felipe dismissed in a 2-0 defeat at Anfield back in November 2021, before Antoine Griezmann saw red in the reverse group stage fixture at the Estadio Metropolitano, where Liverpool emerged 3-2 victors.
They were frustrated against Burnley at the weekend, but eventually found a way to win, and this should be another difficult encounter for them, but one that they should take maximum points from.
Head to head (h2h) history and results
Liverpool vs Atletico Madrid match odds
Atletico Madrid to win: 4/1
Odds via Betfair (subject to change).
