Mikel Arteta’s side top the Premier League table after 11 games and are unbeaten in 14 across all competitions.
They were pegged back in the last minute by Sunderland in a 2-2 draw last time out, as Brian Brobbey struck in injury time.
Spurs, meanwhile, conceded a stoppage-time equaliser of their own against Manchester United, as Matthijs de Ligt snatched a point for ten-man United at the Tottenham Hotspur Stadium.
Arsenal will be without Gabriel but could welcome back a couple of key players, with Noni Madueke and Gabriel Martinelli both nearing returns.
There are question marks over Viktor Gyokeres and Martin Odegaard, while Riccardo Calafiori is a doubt following the international break.
As for Tottenham, Dominic Solanke’s comeback trail remains slow, while Radu Dragusin and Mohammed Kudus could both be included here.
How to watch Arsenal vs Tottenham
TV channel: In the UK, the game will be televised live on Sky Sports Main Event and Sky Sports Premier League, with coverage starting at 4pm GMT.
Live stream: Sky Sports subscribers can also catch the contest live online via the Sky Go app and website.
Live blog: You can follow all the action on matchday via Standard Sport’s live blog, with expert analysis from Simon Collings and Matt Verri at the ground.
