Ruben Amorim’s side claimed a stunning 2-1 victory over Liverpool at Anfield last time out, with Harry Maguire rising highest to nod home an 84th-minute winner.
Bryan Mbeumo had opened the scoring before Cody Gakpo equalised, but Maguire strike late on to snatch all three points.
It followed United’s 2-0 win over Sunderland at Old Trafford, as they bounced back from a disappointing 3-1 defeat at Brentford.
They face a Brighton team that beat Newcastle 2-1 last time out, and they are unbeaten in their last five games in all competitions.
The Seagulls swept Chelsea aside 3-1 at Stamford Bridge before a 1-1 draw with Wolves at Molineux.
How to watch Manchester United vs Brighton
TV channel: In the UK, the game will be televised live on Sky Sports Premier League and Sky Sports Main Event, with coverage starting from 5pm BST ahead of a 5.30pm kick-off.
Live stream: Sky Sports subscribers can also catch the contest live online via the Sky Go app and website.
Live blog: You can follow all the action on matchday via Standard Sport’s live blog!
