Monday, December 1, 2025

Ozempic: The dos and don’ts of coming off GLP-1s — to keep the weight off for good

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STYLE

Arguably, the hardest part of weight loss isn’t really the loss at all — it’s what to do after to maintain it, once you get off a diet and reemerge into the world of adjusted normalcy.

This can be especially true after taking GLP-1 drugs, such as Ozempic and Mounjaro — which can help people to lose an average of 15 to 20 per cent of their body weight. The drugs can help to quite food noise, as well as increasing satiety and slowing gastric emptying, all of which contribute to feeling more full. As a result, according to some doctors, the rapid weight loss can trigger ‘rebound weight gain’ once treatment stops. And right now there are many reasons people are ending their course of the drugs — whether it’s due to expense (Mounjaro had a price rise of almost 170 per cent in autumn), reaching their desired weight, because of unwanted side-effects, or loss of enjoyment from food.



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